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《自然》及子刊综览
来源:中国科学报      作者:冯维维      时间:2017-02-21 17:56      关键词:

《自然》

早期大脑发育或能预测两岁时

自闭症诊断结果

一项小型神经成像研究发现,一岁前脑容量增长比发育正常的婴儿更快,或能在两岁时准确预测自闭症谱系障碍的高风险儿童是否会患病。要将这种潜在的脑生物标志物开发为临床工具,为高风险人群的早期诊断提供信息,研究者还需要进一步的研究,包括在更大的样本中重复实验。相关成果2月16日在线发表于《自然》。

此前,研究者曾在自闭症儿童中观察到过脑容量增大,但并不清楚这种变化的发生过程以及它们与自闭症谱系障碍的行为症状的关系。

美国北卡罗来纳大学教堂山分校Heather Hazlett及同事对106个哥哥或姐姐被临床诊断为自闭症的婴儿(高风险组)以及42个直系亲属中没有自闭史的婴儿(低风险组),开展了一项前瞻性研究。作者分析了在婴儿6至24个月龄间取得的神经成像数据,发现与低风险婴儿和后来未被诊断出自闭症的高风险婴儿相比,后来被诊断出自闭症的高风险婴儿皮层表面区域生长更快。皮层表面区域生长加快与研究者在高风险婴儿两岁期间观察到的脑部整体过度生长有关。他们还发现,脑容量变化也与婴儿两岁期间开始出现的社会技能缺陷有关。最后,研究人员使用机器学习算法,准确预测了哪些高风险儿童在24月龄时将被诊断为自闭症。不过,他们指出目前仍不清楚这些大脑变化是自闭症特有的,还是与其他神经发育障碍相重合。

《自然—生态与演化》

研究揭示深海甲壳动物受污染

一篇论文报告称,研究者在地球最深的两大海沟中发现了极高水平的污染。该研究指出,在远离工业区、彼此间隔近7000千米、且超过10千米深的海沟中发现了如此之高的污染水平,表明人类产生的表面污染能到达地球上最偏远的角落。相关成果2月14日在线发表于《自然—生态与演化》。

英国阿伯丁大学的Alan Jamieson及同事发现,生活在海平面以下10千米的端足目甲壳动物所含的污染物水平和骏河湾接近;骏河湾是西北太平洋污染最严重的工业区之一。他们使用了能深入马里亚纳海沟和克马德克海沟的深海探测器,以取回生活在海沟最深处的生物样本。研究者在这些端足类动物的脂肪组织中发现了极高水平的持久性有机污染物(POP),包括常用作电介液的多氯联苯(PCB)和常用作阻燃剂的多溴二苯醚(PBDE)。

研究人员指出,这些污染物很有可能是通过受污染的塑料碎片掉落到海底并进入海沟的,并被端足目动物所食。

在同期评论文章中,澳大利亚新南威尔士大学Katherine Dafforn表示:“Jamieson及同事用明确的证据证明,深海并不偏远,而是与地表水有高度联系,并且已暴露在大量人类产生的污染物中。”

《自然》

丘吉尔探讨外星生命可能性

在一篇新发现的由英国前首相温斯顿·丘吉尔撰写的文章中,这位英国政治家像科学家一样探讨了其他星球上存在生命的可能性。美国马里兰州巴尔的摩市天体物理学家Mario Livio在这篇近日发表于《自然》的文章中写道:“在当下一些政客拒绝科学的背景下,这位深入探讨科学问题的国家领导人让我十分感动。”

这篇长达11页的文章写作于1939年,当时欧洲正处在战争边缘。文章由打字机打出,原本或打算作为一篇科普文章向报纸投稿。丘吉尔在上世纪50年代补充了这篇文章的内容,但它从未被发表过。文章在上世纪80年代被美国国家丘吉尔博物馆接管。新上任馆长在去年发现了这篇文章,并将它转交给Livio检验其科学性。

Livio赞扬了丘吉尔对当时科研状况的了解和他在科学上的先见之明。在人类发现太阳系外行星前的半个世纪,丘吉尔就在考虑与今天的天体生物学研究课题极为接近的问题了。丘吉尔将生命定义为“繁殖扩增”的能力,并指出了液态水的重要性。他提出,要支持生命存在,行星的温度必须在“水的冰点以上,沸点以下”。

(冯维维/编译 更多信息请访问www.naturechina.com/st)


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