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肠道微生物影响饮食效果
来源:中国科学报      作者:张章      时间:2017-01-10 17:22      关键词:

 

本报讯 当你试着在新年里改善自己的饮食时,体内的微生物群却可能会“捣乱”。近日,刊登在《细胞—宿主和微生物》期刊上的论文称,研究人员探索了为何小鼠从自由的美式饮食转换到健康低卡路里的植物性饮食后,没有立刻出现效果。他们发现,若想一项新饮食计划取得成功,必须去除某些人体肠道细菌。

“如果我们想开饮食处方改善健康,必须弄清哪些微生物能控制有效成果。”论文资深作者、美国华盛顿大学基因组科学与系统生物学中心主任Jeffrey Gordon说,“我们已经找到了一种方法挖掘不同人类的肠道微生物群落,以识别有助于促进特定饮食效应的生物体。”

为了研究人类饮食习惯如何影响肠道微生物群,以及从原有饮食方式变成新饮食方式时,微生物群是如何做出反应的。Gordon 和合作者首先采集了遵循卡路里限制、植物丰富的饮食者和典型美国饮食者的粪便样品。研究人员发现,前者具有更多样化的微生物群。

之后,研究人员给无菌小鼠注射了不同的人类肠道微生物群落,并为其喂食微生物供者的常规饮食或其他饮食类型。虽然两组小鼠对新饮食习惯都有反应,但有美国饮食者的微生物群的小鼠,对于富含植物的饮食反应较弱。

他们又在小鼠之间建立了一系列的阶段共养。结果表明,来自植物饮食者的微生物进入美国饮食者的微生物群后,能显著改善小鼠对植物饮食的反应。

“我们的肠道微生物群落不是孤立的岛屿,而是群岛的一部分,微生物可以从岛屿移动到岛屿,我们称这个群岛是一个集合群落。”论文第一作者Nicholas Griffin 说,“许多迁移到由美国饮食调节的微生物群落的肠道细菌,最初在很多非限制性饮食的肠道微生物中不存在。”

研究人员表示,该结论将有助于指导新策略的发展,以提高健康饮食的处方效率,但他们也强调,需要更多研究确定决定人与人之间微生物交流的因素。(张章)


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