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来源:中国科学报      作者:张笑      时间:2015-05-06 20:34      关键词:自然子刊综览

《自然—神经科学》

科学家发现大脑形成决策的区域

《自然—神经科学》上的一项研究发现了大脑中负责编码进攻和防御策略的区域。该研究选择日本象棋选手的大脑活动作为监测对象,得出的结论或能为科学家研究人类如何作出复杂决定提供新见解。

大量与大脑决策有关的研究所聚焦的都是在各种不同成本和风险之间,人会作出何种决定。这些决定依赖于所采取的全局策略,但这种策略本身是如何被大脑选中的一直是未知。日本象棋能够很好地便于区分大脑的进攻和防御策略,因为这两者之间有着强烈的对比区分。

Keiji Tanaka等人利用功能磁共振成像技术监测了17名高水平的日本象棋业余组选手在判断一些特定棋局应该选择进攻还是防守时的大脑活动情况。在第二次试验中,选手被要求为预设棋局和走棋策略选择具体走哪步棋。这样一来,研究人员便能确定大脑中负责编码走棋策略而非具体到走哪步棋的特定区域。

他们发现在具体走哪步棋前,大脑中就已经形成了走棋策略,这印证了之前的一个观点:我们首先采取策略,之后再根据各种限制条件选择特定的步骤。进攻和防守策略所形成的大脑区域分别为:后扣带回皮质(PCC)和吻侧前扣带皮层(rACC)。此外,背外侧前额叶皮层(dlPFC)的活动也与进攻和防守策略之间的区分有着最紧密关联,这意味着dlPFC在决策选择中也起着一定作用。

《自然》

两种药物或能用于治疗多发性硬化症

《自然》杂志报道了两种获得美国药监局(FDA)批准的药物在修复受损神经以及减轻患多发性硬化症(MS)的小鼠的疾病程度方面有着促进作用。此外,这两种药物在人体干细胞实验中也能增强那些负责支持和保护神经细胞的细胞产生过程。不过,在用于MS患病人体测试前,还需要进一步研究这两种药物的长效性和任何潜在有害影响。

MS是一种炎症,表现症状为神经细胞的髓鞘(一种保护性蛋白膜)会受到免疫系统攻击。在MS的治疗手段中,通过促进少突胶质细胞(制造髓鞘所需的一种细胞)的产生来修复受损髓鞘是一个不错的备选方法。Paul Tesar等人筛选了727种临床试验中可以安全使用的药物来测试其能否促使来源为小鼠干细胞的少突胶质前体细胞发育为成熟的少突胶质细胞。他们发现两种药物——咪康唑(一种抗真菌剂)和丙酸氯倍他索(一种类固醇)——能够显著增加新生少突胶质细胞的数量,并增强小鼠细胞培养和小鼠幼仔体内中髓鞘的生产,同时还能促进人体少突胶质前体细胞的发育成熟。

研究人员注意到,咪康唑和丙酸氯倍他索目前只能作为人体外用药,要想将其用于MS治疗,还需要进行剂量、给药和化学成分的进一步优化,从而查明任何有害影响并确保其不会发生。

(张笑/编译 更多信息请访问www.naturechina.com/st)


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